2' and/or 3' prodrugs of 1', 2', 3' or 4'-branched nucleosides, and their
pharmaceutically acceptable salts and derivatives are described. These
prodrugs are useful in the prevention and treatment of Flaviviridae
infections, including HCV infection, and other related conditions.
Compounds and compositions of the prodrugs of the present invention are
described. Methods and uses are also provided that include the
administration of an effective amount of the prodrugs of the present
invention, or their pharmaceutically acceptable salts or derivatives.
These drugs may optionally be administered in combination or alteration
with further anti-viral agents to prevent or treat Flaviviridae
infections and other related conditions.