Methods and compositions are disclosed that are useful for the prevention
and/or treatment of cancer, angiogenesis, and inflammation. The
beneficial effects of the compositions and methods are achieved through
the use of pharmaceutical compositions that include agents that bind
spingolipids or sphingolipid metabolites. In one embodiment the agent is
an antibody or antibody derivative. In some embodiments, the agent is a
receptor of a sphingolipid or a sphingolipid metabolite. Also disclosed
are methods for identifying and isolating therapeutic agents.