This invention relates to a new family of secreted proteins, termed the
SECFAMI family, its family members including the novel proteins INSP113,
INSP114, INSP115, INSP116 and INSP117, herein identified as secreted
proteins containing epidermal growth factor (EGF) fold-containing
domains, ranging from 125-153 amino acids in length and containing eight
conserved cysteine residues and to the use of these proteins and nucleic
acid sequences from the encoding genes in the diagnosis, prevention and
treatment of disease.