The invention relates to an antagonist of one or more of Rho family
members having ability to elicit neurite outgrowth from cultured neurons
in an assay method which includes culturing neurons on a substrate that
incorporates a growth-inhibiting amount of Rho family member and exposing
the cultured neurons to a candidate Rho family member antagonist agent to
permit neuron growth. Candidates which elicit neurite outgrowth from the
cultured neurons are thus identified as Rho family antagonists.