Methods to elevate progenitor and stem cell counts in animal subjects
using compounds which bind to the chemokine receptor CXCR4 are disclosed.
Preferred embodiments of such compounds are of the formula Z-linker-Z'
(1) or pharmaceutically acceptable salt thereof wherein Z is of the
formula ##STR00001## wherein A comprises a monocyclic or bicyclic
fused ring system containing at least one N and B is H or an organic
moiety of 1 20 atoms, Z' is of the formula --Ar(Y).sub.j; wherein Ar is
an aromatic or heteroaromatic moiety, and each Y is independently a
non-interfering substituent and j is 0 3; and "linker" represents a bond,
alkylene (1 6C) or may comprise aryl, fused aryl, oxygen atoms contained
in an alkylene chain, or may contain keto groups or nitrogen or sulfur