The invention provides a SHINC-2 polynucleotide, which can be a nucleic
acid encoding all or a portion of a SHINC-2 protein, or a complementary
polynucleotide or antisense polynucleotide. The invention provides a
SHINC-2 polypeptide, which can be a full-length SHINC-2 protein or a
fragment thereof or an analog or homolog thereof. Desirably, the SHINC-2
polypeptide modulates apoptosis. The invention provides an antibody that
specifically binds a SHINC-2 polypeptide. The invention provides
diagnostic methods. For example, the invention affords a method for
identifying compounds that modulate apoptosis. The invention provides a
method for detecting or evaluating the prognosis of a cancer. The
invention provides diagnostic compositions for detection of cancer. The
invention provides a method of modulating apoptosis or treating or
preventing a cancer, tumor growth and/or metastasis by administration of
an agent that modulates the expression and/or activity of SHINC-2. The
invention provides formulations of SHINC-2 polynucleotides or proteins.
Preferably, such compositions will comprise liposomal formulations.