Compositions and methods are provided for the treatment and diagnosis of
diseases amenable to modulation of the production of selected proteins.
In accordance with preferred embodiments, oligonucleotides and
oligonucleotide analogs are provided which are specifically hybridizable
with a selected sequence of RNA or DNA wherein at least one of the
2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment
of diseases caused by various viruses and other causative agents is