The present invention features mutated forms of PPAR ligand binding domain
polypeptides that: (1) bind a partial PPAR agonist; and (2) is bound or
activated by a full PPAR agonist to a lesser extent than the wild-type
receptor. The mutated ligand binding domain contains an amino acid
sequence wherein one or more interactions that preferentially (preferably
solely) occurs between a full PPAR agonist and the AF-2 domain of a
wild-type PPAR are modified. Preferably, the mutated ligand binding
domain is selectively bound or activated by a partial PPAR agonist.