The present invention concerns methods for de-differentiation and
stabilize cells, such as progenitor cells, by introducing the cells into
the cytoplasm of host oocytes, such as Xenopus laevis oocytes.
Advantageously, this method obviates the need for any nuclear transfer
procedure, which is known to disrupt the chromosomal architecture of
donor and recipient cells. The present invention also concerns host
oocytes encapsulating cells that have been introduced into their
cytoplasm. The present invention also concerns cells that have been
removed from the host oocytes.