Compositions and methods are disclosed for stimulating or inhibiting
angiogenesis and/or cardiovascularization in mammals, including humans.
Pharmaceutical compositions are based on polypeptides or antagonists
thereto that have been identified for one or more of these uses.
Disorders that can be diagnosed, prevented, or treated by the
compositions herein include trauma such as wounds, various cancers, and
disorders of the vessels including atherosclerosis and cardiac
hypertrophy. In addition, the present invention is directed to novel
polypeptides and to nucleic acid molecules encoding those polypeptides.
Also provided herein are vectors and host cells comprising those nucleic
acid sequences, chimeric polypeptide molecules comprising the
polypeptides of the present invention fused to heterologous polypeptide
sequences, antibodies which bind to the polypeptides of the present
invention and to methods for producing the polypeptides of the present