Anti-TNF antibodies, fragments and regions thereof which are specific for
human tumor necrosis factor-.alpha. (TNF.alpha.) and are useful in vivo
diagnosis and therapy of a number of TNF.alpha.-mediated pathologies and
conditions, as well as polynucleotides coding for murine and chimeric
antibodies, methods of producing the antibody, methods of use of the
anti-TNF antibody, or fragment, region or derivative thereof, in
immunoassays and immunotherapeutic approaches are provided.