The present invention relates to a novel recombinant Sabin type 1
poliovirus vector for the immunogenicity of neutralizing antibody against
polioviral infection, which comprises: (a) a genomic nucleotide sequence
of a parent Sabin type 1 poliovirus; (b) a nucleotide sequence encoding
an additional polioviral cleavage site; and (c) a nucleotide sequence of
a conformational epitope encoding a VP1 neutralizing epitope of
poliovirus type 2 or 3 and linked to the nucleotide sequence of (b).